Astera Blog

Why Rejuvenome Uses Diverse Mice

The workhorse of mammalian biomedical research is a mouse strain known as C57BL/6. These mice are isogenic: they are all genetically identical. In addition to that, these mice are also homozygous at all sites of their genomes. This is achieved by crossing the mice with each other, brother-to-sister, a process called inbreeding. In an ideal […]

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Longevity

Longevity

The Rejuvenome: Goals and Design

Overarching Goals and Structure The Rejuvenome is designed to uncover the effects of aging-interventions (treatments targeting the biological processes of aging) throughout the entire body, spanning molecular and cellular changes to functional differences of individual organs and the body as a whole. For robustness, the study will use genetically diverse mice that more closely resemble […]

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Longevity

Longevity

Why Rejuvenome?

What can we do to most improve human health? How can we help people live longer, healthier lives? Several things come to mind: eradicating infectious disease, eliminating poverty and homelessness, protecting the environment. There are many efforts in these areas, and more are urgently needed. But what is not widely understood is that the process […]

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Longevity

Longevity